Detalhe da pesquisa
1.
Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir.
Nature
; 613(7944): 558-564, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36351451
2.
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.
Nature
; 622(7982): 376-382, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37696289
3.
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.
Proc Natl Acad Sci U S A
; 121(15): e2316662121, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38557187
4.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
5.
Massively multiplexed nucleic acid detection with Cas13.
Nature
; 582(7811): 277-282, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32349121
6.
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges.
Drug Resist Updat
; 73: 101053, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301487
7.
Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel.
Proc Natl Acad Sci U S A
; 119(42): e2210724119, 2022 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36191180
8.
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
Proc Natl Acad Sci U S A
; 119(30): e2203660119, 2022 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858448
9.
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Proc Natl Acad Sci U S A
; 119(36): e2206104119, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037386
10.
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients.
J Infect Dis
; 229(2): 413-421, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506264
11.
Microsecond dynamics of H10N7 influenza neuraminidase reveals the plasticity of loop regions and drug resistance due to the R292K mutation.
J Comput Chem
; 45(5): 247-263, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37787086
12.
Variable antiviral activity of islatravir against M184I/V mutant HIV-1 selected during antiretroviral therapy.
J Antimicrob Chemother
; 79(2): 370-374, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38153245
13.
Temporal trends and transmission dynamics of pre-treatment HIV-1 drug resistance within and between risk groups in Kenya, 1986-2020.
J Antimicrob Chemother
; 79(2): 287-296, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091580
14.
HIV-1 3'-Polypurine Tract Mutations Confer Dolutegravir Resistance by Switching to an Integration-Independent Replication Mechanism via 1-LTR Circles.
J Virol
; 97(5): e0036123, 2023 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125907
15.
Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility.
J Virol
; 97(7): e0015423, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37404185
16.
Influenza A virus polymerase acidic protein E23G/K substitutions weaken key baloxavir drug-binding contacts with minimal impact on replication and transmission.
PLoS Pathog
; 18(7): e1010698, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35830486
17.
Rate of response to initial antiretroviral therapy according to level of pre-existing HIV-1 drug resistance detected by next-generation sequencing in the strategic timing of antiretroviral treatment (START) study.
HIV Med
; 25(2): 212-222, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37775947
18.
Virological characterization of treatment failures and retreatment outcomes in patients infected with "unusual" HCV genotype 1 subtypes.
Hepatology
; 78(2): 607-620, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999537
19.
Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system.
Hepatology
; 78(2): 621-636, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999539
20.
Optimization of an allelic discrimination real-time RT-PCR assay for detection of H275Y oseltamivir resistance gene mutation among influenza A(H1N1)pdm09 patients from 2020 to 2022.
J Med Virol
; 96(2): e29427, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38288882